Mukairu is a youth product of the Nigerian FC Hearts Academy, and moved to the Turkish club Antalyaspor in 2019.[2] He made his professional and Süper Lig debut with Antalyaspor in a 1–0 win over Göztepe S.K. on 18 August 2019.[3] He moved to Anderlecht on loan in the Belgian First Division A for the 2020-21 season, before returning to Antalyaspor.[4] After scoring 8 goals in 53 games in all competitions with Antalyaspor, he transferred to the Danish club F.C. Copenhagen on 27 January 2022 on a 3-year contract.[5]
On 16 August 2023, Mukairu joined League One club Reading on a season-long loan deal.[6]