Patriarch Sophronius may refer to:

• Sophronius of Jerusalem, ruled in 634–638
• Patriarch Sophronius I of Alexandria, ruled in 841–860
• Sophronius I of Constantinople, ruled in 1463–1464
• Patriarch Sophronius II of Alexandria, Greek Patriarch of Alexandria in 941
• Sophronius II of Constantinople, Ecumenical Patriarch in 1774–1780
• Patriarch Sophronius III of Alexandria, ruled in 1116–1171
• Sophronius III of Constantinople, ruled in 1863–1866
• Patriarch Sophronius IV of Alexandria, ruled in 1870–1899 (same person than Sophronius III of Constantinople)

This disambiguation page lists articles associated with the title Patriarch Sophronius.
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