Ghosh started his career in Hindi cinema as an assistance director with small films (1985). His first big directorial film was100 Days(1991). The film was a superhit. It was a remake of Tamil Film Nooravathu Naal. His movie Dalaal(1993), was one of highest grossing Movie in 1993. As of 2015[update], he had written and directed more than 15 movies. Another hit movie Tisra kaun(1994), this film is the remake of 1990 Malayalam film No.20 Madras Mail directed by Joshiy, starring Mohanlal in lead role.
In 2010, Ghosh directed Ek Second... Jo Zindagi Badal De? and Rehmat Ali - 2010. Currently Ghosh has written Agni Shakhi(Part2) and Dalal (Part 2) these two movie may came in 2016. He has also Produced and directed several Bengali films and TV Serials.