Papo is a surname and a masculine given name and nickname. It may refer to:
Surname
- Eliezer Papo (1785–1828), rabbi and writer in the Ottoman Empire
- Hope Papo, South African politician
- Izidor Papo (1913–1996), Austro-Hungarian surgeon, officer, military medical chief and academician
- Roza Papo (1914–1984), Yugoslav physician and general
Given name
- Papo Colo (born 1946), Puerto Rican performance artist, painter, writer and curator
- Papo Lucca (born 1946), Puerto Rican musician
Nickname