Upon completing her formal education, Abshire accepted a faculty appointment at the University of Maryland, College Park (UMD) in November 2001.[1] Early in her career at UMD, she received the 2003 National Science Foundation (NSF) Faculty Early Career Development (CAREER) Award.[2] As an assistant professor, Abshire, Benjamin Shapiro, and Elisabeth Smela received the 2005 Invention of the Year award for their invention, "Cell Sensor Based Pathogen Detection."[3] Later, she began working on sensors that take advantage of the sensory capabilities of biological cells.[4]
In 2009, Abshire, Smela, and Sarah Bergbreiter won a three-year, $1.5 million NSF grant for Ant-Like Microrobots—Fast, Small, and Under Control.[5] Two years later, she was the co-recipient of the Jimmy H. C. Lin Award for Entrepreneurship along with Marc Dandin and David Sander, "in recognition of their business plan Ibis Microtech, a new entrepreneurial venture aiming to equip medical professionals, food quality control technicians, first responders, and national defense agencies with cost-effective diagnostics devices capable of performing laboratory-grade analyses on-site, and in record time."[6]
During her tenure at UMD, Abshire has focused her research on CMOS biosensors; adaptive integrated circuits (ICs) and IC sensors; hybrid microsystems incorporating CMOS, MEMS, optoelectronics, microfluidics, and biological components; low power mixed-signal ICs for a variety of applications, including cell-based sensing, high performance imaging, miniature robotics, spike sorting, adaptive data conversion, and closed loop control of MEMS and microfluidic systems.[7] In 2017, Abshire was promoted to the rank of Full Professor in the A. James Clark School of Engineering's Electrical and Computer Engineering Department.[8] She was elected a Fellow of the Institute of Electrical and Electronics Engineers (IEEE) in 2018 for her "contributions to CMOS biosensors."[7] During the COVID-19 pandemic, Abshire received funding for her project "Tackling Chronic Pain: Machine Learning-Enabled Biomarker Discovery and Sensing" with Reza Ghodssi and Behtash Babadi.[9] She was later named one of the University of Maryland's 2020-2021 ADVANCE Professors, who "serve as strategic mentors and knowledge brokers for faculty within their college."[10]