2P8E
5495
19043
ENSG00000138032
ENSMUSG00000061130
O75688
P36993
NM_001033556NM_001033557NM_002706NM_177968NM_177969
NM_001159496NM_001159497NM_001159498NM_011151
NP_001028729NP_002697NP_808907NP_808908
NP_001152968NP_001152969NP_001152970NP_035281
Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.[5][6]
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.[6]
PPM1B has been shown to interact with:
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
Lokasi Pengunjung: 3.149.29.210