POP5

POP5

Identifiers

POP5, HSPC004, RPP2, RPP20, hPop5, POP5 homolog, ribonuclease P/MRP subunit

External IDs

OMIM: 609992; MGI: 2151221; GeneCards: POP5

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q24.31	Start	120,578,764 bp^[1]
Band	12q24.31	End	120,581,402 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 F	Start	115,373,895 bp^[2]
Band	5\|5 F	End	115,383,410 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

mucosa of transverse colon

right adrenal gland

right adrenal cortex

anterior pituitary

left adrenal cortex

right lobe of thyroid gland

left lobe of thyroid gland

right lobe of liver

right uterine tube

spleen

Top expressed in

dentate gyrus of hippocampal formation granule cell

right kidney

superior frontal gyrus

embryo

yolk sac

primary visual cortex

facial motor nucleus

embryo

proximal tubule

human kidney

More reference expression data


More reference expression data

Gene ontology
Molecular function	ribonuclease activity protein binding hydrolase activity ribonuclease P activity
Cellular component	nucleolus nucleolar ribonuclease P complex nucleus nucleoplasm ribonuclease MRP complex multimeric ribonuclease P complex
Biological process	RNA metabolic process RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic tRNA processing protein lipoylation tRNA 5'-leader removal rRNA processing
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


51367


117109


ENSG00000167272


ENSMUSG00000060152


Q969H6


Q9DB28

RefSeq (mRNA)


NM_015918 NM_198201 NM_198202


NM_026398

RefSeq (protein)


NP_057002 NP_937845


NP_080674 NP_001390591

Location (UCSC)

Chr 12: 120.58 – 120.58 Mb

Chr 5: 115.37 – 115.38 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Ribonuclease P/MRP protein subunit POP5 is an enzyme that in humans is encoded by the POP5 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167272 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060152 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ van Eenennaam H, Lugtenberg D, Vogelzangs JH, van Venrooij WJ, Pruijn GJ (Aug 2001). "hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases" (PDF). J Biol Chem. 276 (34): 31635–41. doi:10.1074/jbc.M103399200. PMID 11413139.
^ "Entrez Gene: POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
van Eenennaam H, Pruijn GJ, van Venrooij WJ (1999). "hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes". Nucleic Acids Res. 27 (12): 2465–72. doi:10.1093/nar/27.12.2465. PMC 148449. PMID 10352175.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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