PODXL2
| PODXL2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | PODXL2, EG, PODLX2, podocalyxin like 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 616627; MGI: 2442488; GeneCards: PODXL2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Podocalyxin like 2 is a protein that in humans is encoded by the PODXL2 gene.[5]
Structure
This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012].
Function
Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000114631 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033152 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Podocalyxin like 2". Retrieved 2017-10-11.
Further reading
- Fieger CB, Sassetti CM, Rosen SD (2003). "Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x". J. Biol. Chem. 278 (30): 27390–8. doi:10.1074/jbc.M304204200. PMID 12889478.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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