PIGQ

PIGQ

Identifiers

PIGQ, GPI1, c407A10.1, phosphatidylinositol glycan anchor biosynthesis class Q, EIEE77, DEE77, MCAHS4, GPIBD19

External IDs

OMIM: 605754; MGI: 1333114; HomoloGene: 31228; GeneCards: PIGQ; OMA:PIGQ - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p13.3	Start	566,995 bp^[1]
Band	16p13.3	End	584,109 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 A3.3	Start	26,145,395 bp^[2]
Band	17\|17 A3.3	End	26,163,910 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right lobe of thyroid gland

right uterine tube

left lobe of thyroid gland

right testis

anterior pituitary

left testis

right frontal lobe

body of pancreas

right hemisphere of cerebellum

right adrenal cortex

Top expressed in

fetal liver hematopoietic progenitor cell

motor neuron

substantia nigra

fossa

ciliary body

endocardial cushion

barrel cortex

medullary collecting duct

ascending aorta

crypt of lieberkuhn of small intestine

More reference expression data


More reference expression data

Gene ontology
Molecular function	transferase activity phosphatidylinositol N-acetylglucosaminyltransferase activity glycosyltransferase activity
Cellular component	integral component of membrane endoplasmic reticulum membrane glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex membrane
Biological process	GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane carbohydrate metabolic process
Sources:Amigo / QuickGO

Species

Human

Mouse


9091


14755


ENSG00000007541


ENSMUSG00000025728


Q9BRB3


Q9QYT7

RefSeq (mRNA)


NM_148920 NM_004204


NM_001291025 NM_011822 NM_001357592

RefSeq (protein)


NP_004195 NP_683721


NP_001277954 NP_035952 NP_001344521

Location (UCSC)

Chr 16: 0.57 – 0.58 Mb

Chr 17: 26.15 – 26.16 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.^[5]^[6]^[7]

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).^[7]

Interactions

PIGQ has been shown to interact with PIGH,^[5] PIGA^[5] and PIGC.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007541 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025728 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c ^d Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T (Mar 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. 17 (4): 877–85. doi:10.1093/emboj/17.4.877. PMC 1170437. PMID 9463366.
^ Tiede A, Schubert J, Nischan C, Jensen I, Westfall B, Taron CH, Orlean P, Schmidt RE (Nov 1998). "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants". Biochem J. 334 (3): 609–16. doi:10.1042/bj3340609. PMC 1219730. PMID 9729469.
^ ^a ^b "Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q".

Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tiede A, Daniels RJ, Higgs DR, et al. (2001). "The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis". Gene. 271 (2): 247–54. doi:10.1016/S0378-1119(01)00510-8. PMID 11418246.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Watanabe R, Murakami Y, Marmor MD, et al. (2000). "Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2". EMBO J. 19 (16): 4402–11. doi:10.1093/emboj/19.16.4402. PMC 302040. PMID 10944123.
Hong Y, Ohishi K, Watanabe R, et al. (1999). "GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis". J. Biol. Chem. 274 (26): 18582–8. doi:10.1074/jbc.274.26.18582. PMID 10373468.
Watanabe R, Kinoshita T, Masaki R, et al. (1996). "PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum". J. Biol. Chem. 271 (43): 26868–75. doi:10.1074/jbc.271.43.26868. PMID 8900170.

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