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PCOLCE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UAP
Identifiers
Aliases	PCOLCE, PCPE, PCPE-1, PCPE1, procollagen C-endopeptidase enhancer
External IDs	OMIM: 600270; MGI: 105099; HomoloGene: 1946; GeneCards: PCOLCE; OMA:PCOLCE - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,608,175 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,612,046 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; periodontal fiber; ; canal of the cervix; ; tendon of biceps brachii; ; tibia; ; cartilage tissue; ; apex of heart; ; gallbladder; ; right coronary artery; ; synovial membrane;
	Top expressed in
	calvaria; ; fossa; ; efferent ductule; ; molar; ; vas deferens; ; ankle; ; umbilical cord; ; external carotid artery; ; body of femur; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; protein binding; peptidase activator activity; collagen binding; extracellular matrix structural constituent;
Cellular component	extracellular matrix; extracellular exosome; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	multicellular organism development; proteolysis; positive regulation of peptidase activity; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	5118
	18542
	ENSG00000106333
	ENSMUSG00000029718
	Q15113
	Q61398
	NM_002593
	NM_008788
	NP_002584
	NP_032814
	Wikidata
View/Edit Human	View/Edit Mouse

Procollagen C-endopeptidase enhancer 1 is an enzyme that in humans is encoded by the PCOLCE gene.^[5]^[6]^[7]

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens activity.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106333 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029718 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takahara K, Osborne L, Elliott RW, Tsui LC, Scherer SW, Greenspan DS (Mar 1997). "Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics. 31 (2): 253–256. doi:10.1006/geno.1996.0043. PMID 8824813.
^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–1073. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
^ ^a ^b "Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer".

Takahara K, Kessler E, Biniaminov L, et al. (1994). "Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE)". J. Biol. Chem. 269 (42): 26280–26285. doi:10.1016/S0021-9258(18)47191-8. PMID 7523404.
Scott IC, Clark TG, Takahara K, et al. (1999). "Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics. 55 (2): 229–234. doi:10.1006/geno.1998.5663. PMID 9933570.
Mott JD, Thomas CL, Rosenbach MT, et al. (2000). "Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor". J. Biol. Chem. 275 (2): 1384–1390. doi:10.1074/jbc.275.2.1384. PMID 10625689.
Ricard-Blum S, Bernocco S, Font B, et al. (2002). "Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1". J. Biol. Chem. 277 (37): 33864–33869. doi:10.1074/jbc.M205018200. PMID 12105202.
Ligon AH, Scott IC, Takahara K, et al. (2002). "PCOLCE deletion and expression analyses in uterine leiomyomata". Cancer Genet. Cytogenet. 137 (2): 133–137. doi:10.1016/S0165-4608(02)00547-2. PMID 12393284.
Steiglitz BM, Keene DR, Greenspan DS (2003). "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1". J. Biol. Chem. 277 (51): 49820–49830. doi:10.1074/jbc.M209891200. PMID 12393877.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bernocco S, Steiglitz BM, Svergun DI, et al. (2003). "Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein". J. Biol. Chem. 278 (9): 7199–7205. doi:10.1074/jbc.M210857200. PMID 12486138.
Liepinsh E, Banyai L, Pintacuda G, et al. (2003). "NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding". J. Biol. Chem. 278 (28): 25982–25989. doi:10.1074/jbc.M302734200. PMID 12670942.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Petropoulou V, Garrigue-Antar L, Kadler KE (2005). "Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1)". J. Biol. Chem. 280 (24): 22616–22623. doi:10.1074/jbc.M413468200. PMID 15817489.
Ge G, Zhang Y, Steiglitz BM, Greenspan DS (2006). "Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains". J. Biol. Chem. 281 (16): 10786–10798. doi:10.1074/jbc.M511111200. PMID 16507574.
Blanc G, Font B, Eichenberger D, et al. (2007). "Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity" (PDF). J. Biol. Chem. 282 (23): 16924–16933. doi:10.1074/jbc.M701610200. PMID 17446170. Archived from the original on 2018-07-23.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106333 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029718 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8824813-5] Takahara K, Osborne L, Elliott RW, Tsui LC, Scherer SW, Greenspan DS (Mar 1997). "Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics. 31 (2): 253–256. doi:10.1006/geno.1996.0043. PMID 8824813.

[pmid9799793-6] Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–1073. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.

[entrez-7] "Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer".

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PCOLCE

References

Further reading