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PCGEM1

Not to be confused with PC GEM.
PCGEM1
Identifiers
AliasesPCGEM1, LINC00071, NCRNA00071, PCAT9, prostate-specific transcript (non-protein coding), prostate-specific transcript, PCGEM1 prostate-specific transcript
External IDsOMIM: 605443; GeneCards: PCGEM1
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

64002

n/a

Ensembl

ENSG00000227418

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 2: 192.75 – 192.78 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human
Prostate-specific transcript 1
Predicted secondary structure and sequence conservation of PCGEM1
Identifiers
SymbolPCGEM1
RfamRF01981
Other data
RNA typeGene;
DomainEukaryota;
GOGO:0042981
SOSO:0001463
PDB structuresPDBe

Prostate-specific transcript 1 (non-protein coding), also known as PCGEM1, is a long non-coding RNA gene. In humans, it is located on chromosome 2q32. It is over-expressed in prostate cancer.[3][4] In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in African-American men than in Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.[5]

PCGEM1 inhibits doxorubicin-induced apoptosis of cells, via delayed induction of p53 and p21.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000227418 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Srikantan V, Zou Z, Petrovics G, et al. (October 2000). "PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 12216–12221. Bibcode:2000PNAS...9712216S. doi:10.1073/pnas.97.22.12216. PMC 17321. PMID 11050243.
  4. ^ Bialkowska-Hobrzanska H, Driman DK, Fletcher R, Harry V, Razvi H (February 2006). "Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue". Can J Urol. 13 (1): 2967–2974. PMID 16515751.
  5. ^ Petrovics G, Zhang W, Makarem M, et al. (January 2004). "Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients". Oncogene. 23 (2): 605–611. doi:10.1038/sj.onc.1207069. PMID 14724589.
  6. ^ Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S (March 2006). "Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1". DNA Cell Biol. 25 (3): 135–141. doi:10.1089/dna.2006.25.135. PMID 16569192.

Further reading

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