Otolin
| OTOL1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OTOL1, C1QTNF15, otolin 1, C1QTNF16 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2685260; GeneCards: OTOL1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Otolin is a glycoprotein found in the vertebrate inner ear.[5]
Modifications
Otolin is modified after it is translated, with hydroxylated prolines and two glycosylated lysines with glucosyl-galactosyl groups.[5]
Substructure
The gene for otolin in mice is on chromosome 3E12. In humans it is located at 3q26.1 At the N-terminal end there is a signal peptide. The N-terminal end has four cysteine residues. Adjacent to this is a stiff collagen domain with 75 Gly-X-Y repeats. It also contains a cysteine residue, and in human otolin, there are four cystein residues in this domain. At the opposite end is the C1q domain. The otolin gene in mammals contains four introns and five exons.[5]
Superstructure
Otolin combines with several other otolin molecules to form an oligomer, probably a trimer. It also binds to otoconin-90 and cerebellin-1.[5]
Production
Otolin is produced by the vestibular support cells in the utricle, saccule, the three semicircular canal cristae, and the tectorial membrane. In teleosts (fish), otolin is found in the otolith and it is required to anchor the otolith in position.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000182447 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027788 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d e Deans, Michael R.; Peterson, Jonathan M.; Wong, G. William; Hulmes, David John Stuart (15 September 2010). "Mammalian Otolin: A Multimeric Glycoprotein Specific to the Inner Ear that Interacts with Otoconial Matrix Protein Otoconin-90 and Cerebellin-1". PLOS ONE. 5 (9) e12765. Bibcode:2010PLoSO...512765D. doi:10.1371/journal.pone.0012765. PMC 2939893. PMID 20856818. S2CID 8886304.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.