His early work in Chicago was as a carpenter and contractor.[3] One project he worked on was dredging the mouth of the Chicago River.[3]
On August 15, 1835 he was elected the first High Constable and High Collector of Chicago.[4] As High Constable, he was the city's first head of police from his election until May 2, 1837.[5]
Morrison was elected and served as street commissioner.[3][7]
From 1840 to 1841, he served as an alderman from the 1st ward of Chicago.[8]
In 1838, he purchased land on the corner of Clark and Madison in Chicago. This later became the location of the Morrison Hotel, the original building of which was built in 1860.[3][9] He made a number of other real estate purchases in Chicago.[3]
He was married to the former Lucy Paul on April 7, 1836, in Aurora, Erie County, New York.[3]
Morrison died in Chicago on January 4, 1864, and was buried at Graceland Cemetery.[5][10] When he died, he was survived by two daughters, Hannah Spofford and Lucy Mills, the latter of whom was married to congressman Daniel W. Mills.[3][11]