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Ornatin

Ornatin
Identifiers
SymbolOrnatin
PfamPF02088
InterProIPR002463
Available protein structures:
PDB  IPR002463 PF02088 (ECOD; PDBsum)  
AlphaFold

In molecular biology, ornatin is a potent glycoprotein IIb-IIIa (GP IIb-IIIa) antagonist and platelet aggregation inhibitor isolated from Placobdella ornata (Turtle leech).[1] The protein is 41-52 amino acids in length and contains the RGD recognition motif common in adhesion proteins, and 6 conserved cysteine residues. These form three disulphide bonds, which are required for activity.[2] The sequences of ornatin B, C, D and E are highly similar, while A2 and A3 are less similar, lacking the N-terminal 9 residues. Ornatins share ~40% identity with decorsin, a GP IIb-IIIa antagonist isolated from the leech Macrobdella decora.[1]

References

  1. ^ a b Mazur P, Henzel WJ, Seymour JL, Lazarus RA (December 1991). "Ornatins: potent glycoprotein IIb-IIIa antagonists and platelet aggregation inhibitors from the leech Placobdella ornata". Eur. J. Biochem. 202 (3): 1073–82. doi:10.1111/j.1432-1033.1991.tb16472.x. PMID 1765068.
  2. ^ Mazur P, Dennis MS, Seymour JL, Lazarus RA (1993). "Expression, purification, and characterization of recombinant ornatin E, a potent glycoprotein IIb-IIIa antagonist". Protein Expr Purif. 4 (4): 282–9. doi:10.1006/prep.1993.1036. PMID 8374297.
This article incorporates text from the public domain Pfam and InterPro: IPR002463

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