Olfactory glands

Olfactory glands
Section of the olfactory mucous membrane
Details
SystemOlfactory system
Identifiers
Latinglandulae olfactoriae
TA98A15.1.00.003
TA26733
THH3.05.00.0.00026
FMA77659
Anatomical terminology

Olfactory glands, also known as Bowman's glands, are a type of nasal gland situated in the part of the olfactory mucosa beneath the olfactory epithelium, that is the lamina propria, a connective tissue also containing fibroblasts, blood vessels and bundles of fine axons from the olfactory neurons.[1]

An olfactory gland consists of an acinus in the lamina propria and a secretory duct going out through the olfactory epithelium.

Electron microscopy studies show that olfactory glands contain cells with large secretory vesicles.[2] Olfactory glands secrete the gel-forming mucin protein MUC5B.[3] They might secrete proteins such as lactoferrin, lysozyme, amylase and IgA, similarly to serous glands. The exact composition of the secretions from olfactory glands is unclear, but there is evidence that they produce odorant-binding protein.[4][5]

Function

The olfactory glands are tubuloalveolar glands surrounded by olfactory receptors and sustentacular cells in the olfactory epithelium. These glands produce mucus to lubricate the olfactory epithelium and dissolve odorant-containing gases.[citation needed] Several olfactory binding proteins are produced from the olfactory glands that help facilitate the transportation of odorants to the olfactory receptors. These cells exhibit the mRNA to transform growth factor α, stimulating the production of new olfactory receptor cells.

See also

References

Public domain This article incorporates text in the public domain from page 996 of the 20th edition of Gray's Anatomy (1918)

  1. ^ Moran, David T.; Rowley Jc, 3rd; Jafek, BW; Lovell, MA (1982), "The fine structure of the olfactory mucosa in man", Journal of Neurocytology, 11 (5): 721–746, doi:10.1007/BF01153516, PMID 7143026, S2CID 25263022{{citation}}: CS1 maint: numeric names: authors list (link)
  2. ^ Frisch, Donald (1967), "Ultrastructure of mouse olfactory mucosa.", The American Journal of Anatomy, 121 (1): 87–120, doi:10.1002/aja.1001210107, PMID 6052394
  3. ^ Amini, S. E.; Gouyer, V.; Portal, C.; Gottrand, C.; Desseyn, J.-L. (2019), "Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium." (PDF), Histochem Cell Biol, 152 (2): 167–174, doi:10.1007/s00418-019-01785-5, PMID 31030254, S2CID 253886824
  4. ^ Gartner, Leslie P.; Hiatt, James L. (2007). Color Textbook of Histology. Saunders/Elsevier. p. 349. ISBN 978-1-4160-2945-8.
  5. ^ Tegoni, Mariella; Pelosi, P; Vincent, F; Spinelli, S; Campanacci, V; Grolli, S; Ramoni, R; Cambillau, C (2000), "Mammalian odorant binding proteins", Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1482 (1–2) (published 1967): 229–240, doi:10.1016/S0167-4838(00)00167-9, PMID 11058764


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