As a senior, Zaccheaus led the ACC with 93 receptions for 1,058 yards and nine touchdowns and was named first team All-ACC.[4]
He was named the Most Valuable Player of the 2018 Belk Bowl, his final game as a Cavalier, after making 12 receptions for 100 yards receiving and three touchdowns.[5]
Zaccheaus finished his collegiate career with 250 receptions for 2,753 yards and 22 touchdowns while also rushing 79 times for 551 yards and two touchdowns in 50 games played.[6]
Zaccheaus signed with the Atlanta Falcons as an undrafted free agent on April 27, 2019, and made the 53-man roster out of training camp.[8] Zaccheaus made his NFL debut on October 13, 2019, against the Arizona Cardinals, making a tackle on special teams.[9] In the Falcons' 40–20 victory against the Carolina Panthers on December 8, 2019, Zaccheaus recorded his first reception in the NFL,[10] a 93-yard touchdown pass from Matt Ryan, which was the third-longest reception in franchise history, and set an NFL record for the longest first catch.[11] In Week 15 against the San Francisco 49ers, Zaccheaus returned a fumble for a touchdown in the closing seconds of the 29–22 win.[12] Zaccheaus finished his rookie season with three receptions for 115 yards and a touchdown on offense and two tackles and a fumble recovery for a touchdown on special teams.[13]
In Week 9 of the 2020 season against the Denver Broncos, Zaccheaus had his first 100-yard game with four receptions for 103 receiving yards and a touchdown in the 34–27 victory.[14] He was placed on injured reserve on December 1, 2020.[15] Zaccheaus finished the season with 20 receptions for 274 yards and one touchdown in 11 games played.[16]
In Week 8 of the 2021 season against the New Orleans Saints, Zaccheaus had three receptions for 58 yards and a career-high two touchdowns in the 27–25 win.[17] Zaccheaus finished the season with 31 receptions for 406 yards and three touchdowns.[18]
On March 15, 2022, the Falcons placed a restricted free agent tender on Zaccheaus. On April 19, 2022, Zaccheaus signed his right-of-refusal tender, ensuring his return to the Falcons.[19] Zaccheaus played in all 17 games, of which he started 13. He finished with 40 receptions for 533 receiving yards and three receiving touchdowns.[20]
Philadelphia Eagles
On April 20, 2023, Zaccheaus signed a one-year deal with the Philadelphia Eagles.[21] He finished the season with 10 receptions for 164 receiving yards and 2 touchdowns.[22]
In Week 16 of the 2024 season against his former team, the Philadelphia Eagles, Zaccheaus recorded 5 catches for 70 yards and 2 touchdowns in the 36-33 win.[24]
The following week, against another former team, the Falcons, Zaccheaus led the Commanders with 8 catches for 85 yards and a touchdown. [25]