OR51E2

OR51E2
Identifiers
AliasesOR51E2, OR51E3P, OR52A2, PSGR, olfactory receptor family 51 subfamily E member 2, HPRAJ
External IDsOMIM: 611268; MGI: 2157548; HomoloGene: 23713; GeneCards: OR51E2; OMA:OR51E2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

81285

170639

Ensembl

ENSG00000167332

ENSMUSG00000043366

UniProt

Q9H255

Q8VBV9

RefSeq (mRNA)

NM_030774

NM_001168503
NM_130866

RefSeq (protein)

NP_110401

NP_001161975
NP_570936

Location (UCSC)Chr 11: 4.68 – 4.7 MbChr 7: 102.39 – 102.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

Structure

Structure of the olfactory receptor OR51E2 (green) complexed with miniGs399 and a propionic acid ligand (orange).[7]

Its structure was determined in 2023, the first elucidation of the structure of a human olfactory receptor.[7][8][9]

Ligands

OR51E2 is a relatively narrowly tuned olfactory receptor, meaning it responds only to a relatively small set of related odorants.[10]

OR51E2 responds to short-chain fatty acids,[11] including in particular propionic acid.[10]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167332 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043366 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, et al. (December 2000). "PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer". Cancer Research. 60 (23): 6568–6572. PMID 11118034.
  6. ^ a b "Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2".
  7. ^ a b PDB: 8F76​; Billesbølle CB, de March CA, van der Velden WJ, Ma N, Tewari J, Del Torrent CL, et al. (March 2023). "Structural basis of odorant recognition by a human odorant receptor". Nature. 615 (7953): 742–749. Bibcode:2023Natur.615..742B. doi:10.1038/s41586-023-05798-y. PMC 10580732. PMID 36922591. S2CID 254975795.
  8. ^ Kim SE (2023). "Scientists sniff out the structure of a human olfactory receptor". Chemical & Engineering News. 101 (10): 6. doi:10.1021/cen-10110-scicon3.
  9. ^ Parry W (1 May 2023). "How a Human Smell Receptor Works Is Finally Revealed". Quanta Magazine.
  10. ^ a b Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
  11. ^ Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, et al. (March 2013). "Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation". Proceedings of the National Academy of Sciences of the United States of America. 110 (11): 4410–4415. Bibcode:2013PNAS..110.4410P. doi:10.1073/pnas.1215927110. PMC 3600440. PMID 23401498.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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