Nyuksenitsa has been first mentioned in 1619.[8] At the time, the Sukhona was intensively used as a transport waterway, connecting Moscow to Arkhangelsk, till 1703 the main hub of Russian foreign trade. In the 19th century, Nyuksenitsa belonged to Velikoustyugsky Uyezd of Vologda Governorate. In 1918, the area was transferred to the newly established Northern Dvina Governorate, and in 1924 the uyezds were abolished in favor of the new divisions, the districts (raions).
Nyuksensky District was established on June 25, 1924 and included areas of former Solvychegodsky and Velikoustyugsky Uyezds. On February 27, 1928, it was renamed into Sukhonsky District. On July 30, 1931 Sukhonsky and Kokshengsky Districts of the Northern Krai were merged, and Nyuksensky District was re-established, with the administrative center again located in Nyuksenitsa.[9]
Economy
Industry
In Nyuksenitsa, timber and food industry are present, including a milk factory.[10]
Transportation
Nyuksenitsa is on the road connecting Vologda and Veliky Ustyug, and in Nyuksenitsa the road moves over the bridge from the left bank to the right bank of the Sukhona. Another paved road branches off in Nyuksenitsa northwest to Tarnogsky Gorodok and further to Oktyabrsky in Arkhangelsk Oblast. There is regular passenger bus service on both roads.
The Sukhona is navigable within the district, however, there is no passenger navigation.
Законодательное Собрание Вологодской области. Закон №371-ОЗ от 4 июня 1999 г. «О вопросах административно-территориального устройства Вологодской области», в ред. Закона №2916-ОЗ от 7 декабря 2012 г. «О внесении изменений в Закон области "О вопросах административно-территориального устройства Вологодской области"». Вступил в силу со дня официального опубликования. Опубликован: "Красный Север", №124–125, 29 июля 1999 г. (Legislative Assembly of Vologda Oblast. Law #371-OZ of June 4, 1999 On the Matters of the Administrative-Territorial Structure of Vologda Oblast, as amended by the Law #2916-OZ of December 7, 2012 On Amending the Oblast Law "On the Matters of the Administrative-Territorial Structure of Vologda Oblast". Effective as of the day of the official publication.).
Правительство Вологодской области. Постановление №178 от 1 марта 2010 г. «Об утверждении реестра административно-территориальных единиц Вологодской области», в ред. Постановления №686 от 25 июня 2012 г. «О внесении изменений в некоторые Постановления Правительства области». Вступил в силу 20 марта 2010 г. Опубликован: "Красный Север", №29, 20 марта 2010 г. (Government of Vologda Oblast. Resolution #178 of March 1, 2010 On Adopting the Registry of the Administrative-Territorial Units of Vologda Oblast, as amended by the Resolution #686 of June 25, 2012 On Amending Various Resolutions of the Oblast Government. Effective as of March 20, 2010.).
Законодательное Собрание Вологодской области. Закон №1120-ОЗ от 6 декабря 2004 г. «Об установлении границ Нюксенского муниципального района, границах и статусе муниципальных образований, входящих в его состав», в ред. Закона №2809-ОЗ от 5 июля 2012 г. «О внесении изменений в отдельные Законы области, устанавливающие границы и статус муниципальных образований области». Вступил в силу через 10 дней со дня официального опубликования. Опубликован: "Красный Север", №242, 11 декабря 2004 г. (Legislative Assembly of Vologda Oblast. Law #1120-OZ of December 6, 2004 On Establishing the Borders of Nyuksensky Municipal District, on the Borders and Status of the Municipal Formations It Comprises, as amended by the Law #2809-OZ of July 5, 2012 On Amending Various Laws of the Oblast, Establishing the Borders and the Status of the Municipal Formations of the Oblast. Effective as of after 10 days from the day of the official publication.).