Ōoka Tadasuke, the famous magistrate who had served the 9th Tokugawa shōgun, Tokugawa Yoshimune, and who had successfully carried out the Kyōhō Reforms received an additional 4,000 koku in revenue on his promotion to sōshaban in 1748. This put him over the 10,000 koku requirement to be styled as daimyō, and he received the newly created fief of Nishi-Ōhira as his domain. However, he never relocated to his new territory, and resided in Edo to his death in 1757.
Nishi-Ōhira Domain was not a single contiguous territory, but consisted of several widely scattered holdings: in addition to 12 villages in Nukata District, the territory consisted of 5 villages in Kamo District, 5 villages in Hoi District, 2 villages in Omi District in Mikawa, 3 villages in Ichihara District, Kazusa Province and the original 2 villages of the Ōoka clan in Kōza District, Sagami Province.
The domain was inherited by Ōoka Tadasuke's heirs after his death, but it was not until 1748, during the tenure of his grandson, Ōoka Tadatsune, that a jin'ya fortified residence was built in Nishi-Ōhira to be the nominal capital of the domain. Due to its special relationship with the Tokugawa shogunate, the Ōoka clan was one of the few clans exempted from the sankin kōtai regulations, and lived in their Edo residence full-time. The graves of all of the daimyō of Nishi-Ōhira are located at the Ōoka clan temple of Jōken-ji in Chigasaki, Kanagawa.
In the Siege of Osaka in 1615, Tadasuke went to the front with his father Yasutoshi the lord of the Nishio Domain with 20,000 koku. His father Yasutoshi was transferred to Zeze Domain in 1617.
In 1630, 1,500 koku was added and 1000 koku was added in Kozuko and Shimotsuke Province, and a total of 9,000 koku was acquired.
In February 1869, Tadayuki reformed the domain administration organization and established the Legislative and Political Bureau, Accounting Bureau, Military Affairs Bureau, School Bureau.
On July 14, 1871, the Nishibata Domain was abolished due to the abolition of feudal domains and the establishment of prefectures, and the West End Prefecture was established. Due to the integration of prefectures at the end of the same year, the domain was abolished and incorporated into Nukata Prefecture and eventually was incorporated into Aichi Prefecture.