He married Mary Hume, daughter of Sir Gustavus Hume, 3rd Baronet, on 18 August 1736. He was succeeded by his son, Nicholas Hume-Loftus, 2nd Earl of Ely. During the celebrated hearing into the son's mental incapacity, much was said about the ill-treatment he had received from his father.
References
^John Debrett, Debrett's Peerage of England, Scotland, and Ireland (1820), 922.