NH 88 begins in the west at NH 108 on the northern edge of Exeter, less than 1⁄4 mile (0.40 km) from the exit 11 junction with NH 101 (the Exeter-Hampton Expressway) in Stratham. The highway heads southeast, roughly paralleling NH 101 for 1.1 miles before intersecting NH 27/NH 111 east of town. This westernmost stretch of NH 88 is very poorly signed; in fact NH 88 westbound to NH 108 is completely unsigned from NH 27/NH 111. Signage on NH 108 approaching this intersection is ambiguous as to whether Holland Way (the official name of this stretch) is part of NH 88, or simply an access road "To 88". NH 88 briefly (and silently) overlaps NH 27 and NH 111, then NH 88 splits off southeast again and crosses into Hampton Falls. The highway continues for 5.5 miles (8.9 km), passes underneath Interstate 95 without an interchange and then terminates at US 1 in the center of town, just feet from the eastern terminus of NH 84.
Access to I-95 from NH 88 can be facilitated by either NH 107 in Seabrook or NH 101 in Hampton, both via US 1.