Nessie is a nickname of the Loch Ness Monster, a cryptid that reputedly inhabits the Loch Ness lake in Scotland.

Nessie or NESSIE may also refer to:

• Andrew Nesbitt Nessie Snedden (1892–1968), New Zealand cricketer
• Nessie Stewart-Brown (1864–1958), British suffragist and politician

• Renesmee Carlie Cullen or Nessie, in the novel Breaking Dawn, part of the Twilight series
• Vanessa Kapatelis or Nessie, in the Wonder Woman comic books
• Nessie, an amphibious character in the Boneyard comic book series
• Nessie, in Kaiju ouji, a Japanese tokusatsu/kaiju television series

• NESSIE or New European Schemes for Signatures, Integrity and Encryption, a European research project to identify secure cryptographic primitives
• Mitsubishi Nessie, a concept automobile
• Tropical cyclone Nessie, in the 1973–74 South Pacific cyclone season
• Nessie Rock in Antarctica
• Nessie (film), a 2023 British-American film

• National Survey of Student Engagement (NSSE), a survey instrument for student participation levels at universities and colleges in Canada and the United States
• Nessi

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