Nenad Ban is a biochemist born in Zagreb, Croatia who currently works at the ETH Zurich, Swiss Federal Institute of Technology, as a professor of Structural Molecular Biology. He is a pioneer in studying gene expression mechanisms and the participating protein synthesis machinery.
Already in high school he developed an interest in understanding the mechanisms of protein synthesis, which led him to the laboratory of Prof. Zeljko Kucan and Ivana Weygand in Zagreb where he investigated tRNA synthetases, enzymes that charge tRNAs with amino acids to prepare them as substrates for protein synthesis on the ribosome. These interests brought him to the Department of Molecular Biophysics and Biochemistry at Yale University where he determined the atomic structure of the large ribosomal subunit by X-ray crystallography, as part of the group in the laboratory of Thomas A. Steitz. These results demonstrated that the ribosome is a ribozyme.[2]
Since 2000 Nenad Ban is a professor of structural molecular biology at the ETH Zurich.[3] (Swiss Federal Institute of Technology). His group is investigating protein synthesis both in terms of the chemistry of the process and with respect to how it is regulated, how proteins co-translationally fold,[4][5] how they are co-translationally modified,[6] and how they are targeted to membranes[7] and sorted to different cellular compartments.[8][9][10][11]
Nenad Ban’s group at ETH Zurich revealed the mechanisms behind the key steps in eukaryotic cytoplasmic and mitochondrial translation with a broad impact on a wide range of fields in biology, chemistry and biomedicine.[12][13]
His group also contributed to our understanding of giant multifunctional enzymes involved in fatty acid synthesis offering mechanistic insights into substrate shuttling and delivery in such megasynthases.[14][15][16][17][18]
^Ban, Nenad; Nissen, Poul; Hansen, Jeffrey; Moore, Peter B.; Steitz, Thomas A. (11 August 2000). "The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution". Science. 289 (5481). American Association for the Advancement of Science (AAAS): 905–920. Bibcode:2000Sci...289..905B. doi:10.1126/science.289.5481.905. ISSN0036-8075. PMID10937989.
^Schaffitzel, Christiane; Oswald, Miro; Berger, Imre; Ishikawa, Takashi; Abrahams, Jan Pieter; Koerten, Henk K.; Koning, Roman I.; Ban, Nenad (29 October 2006). "Structure of the E. coli signal recognition particle bound to a translating ribosome". Nature. 444 (7118). Springer Science and Business Media LLC: 503–506. Bibcode:2006Natur.444..503S. doi:10.1038/nature05182. hdl:1887/3620885. ISSN0028-0836. PMID17086205. S2CID4400092.
^Klinge, Sebastian; Voigts-Hoffmann, Felix; Leibundgut, Marc; Arpagaus, Sofia; Ban, Nenad (18 November 2011). "Crystal Structure of the Eukaryotic 60 S Ribosomal Subunit in Complex with Initiation Factor 6". Science. 334 (6058). American Association for the Advancement of Science (AAAS): 941–948. Bibcode:2011Sci...334..941K. doi:10.1126/science.1211204. ISSN0036-8075. PMID22052974. S2CID206536444.
^Leibundgut, Marc; Jenni, Simon; Frick, Christian; Ban, Nenad (13 April 2007). "Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase". Science. 316 (5822). American Association for the Advancement of Science (AAAS): 288–290. Bibcode:2007Sci...316..288L. doi:10.1126/science.1138249. ISSN0036-8075. PMID17431182. S2CID32176226.
^Jenni, Simon; Leibundgut, Marc; Boehringer, Daniel; Frick, Christian; Mikolásek, Bohdan; Ban, Nenad (13 April 2007). "Structure of Fungal Fatty Acid Synthase and Implications for Iterative Substrate Shuttling". Science. 316 (5822). American Association for the Advancement of Science (AAAS): 254–261. Bibcode:2007Sci...316..254J. doi:10.1126/science.1138248. ISSN0036-8075. PMID17431175. S2CID12820568.