Nasal embryonic LHRH factor

NSMF

Identifiers

NSMF, HH9, NELF, Nasal embryonic LHRH factor, NMDA receptor synaptonuclear signaling and neuronal migration factor

External IDs

OMIM: 608137; MGI: 1861755; HomoloGene: 10648; GeneCards: NSMF; OMA:NSMF - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q34.3	Start	137,447,570 bp^[1]
Band	9q34.3	End	137,459,334 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 A3	Start	24,944,367 bp^[2]
Band	2\|2 A3	End	24,952,893 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

anterior cingulate cortex

right frontal lobe

Amygdala

prefrontal cortex

Region I of hippocampus proper

ascending aorta

dorsolateral prefrontal cortex

caudate nucleus

Descending thoracic aorta

nucleus accumbens

Top expressed in

medial dorsal nucleus

medial geniculate nucleus

lateral geniculate nucleus

subiculum

anterior amygdaloid area

barrel cortex

suprachiasmatic nucleus

substantia nigra

olfactory tubercle

prefrontal cortex

More reference expression data


More reference expression data

Gene ontology
Molecular function	calcium-dependent protein binding
Cellular component	cytoplasm apical dendrite perikaryon postsynaptic membrane cell projection nuclear membrane nuclear envelope membrane postsynaptic density nuclear matrix cortical cytoskeleton plasma membrane synapse nucleoplasm cell junction dendrite cell cortex neuron projection cytoskeleton nucleus
Biological process	positive regulation of protein dephosphorylation regulation of neuron apoptotic process positive regulation of neuron migration regulation of dendrite morphogenesis cellular response to amino acid stimulus cellular response to gonadotropin stimulus cellular response to electrical stimulus regulation of neuron migration regulation of neuronal synaptic plasticity
Sources:Amigo / QuickGO

Species

Human

Mouse


26012


56876


ENSG00000165802


ENSMUSG00000006476


Q6X4W1


Q99NF2

RefSeq (mRNA)


NM_001130969 NM_001130970 NM_001130971 NM_001178064 NM_015537


NM_001039386 NM_001039387 NM_001177654 NM_001177655 NM_020276

RefSeq (protein)


NP_001124441 NP_001124442 NP_001124443 NP_001171535 NP_056352


NP_001034475 NP_001034476 NP_001171125 NP_001171126 NP_064672

Location (UCSC)

Chr 9: 137.45 – 137.46 Mb

Chr 2: 24.94 – 24.95 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Nasal embryonic luteinizing hormone-releasing hormone factor is a protein that in humans is encoded by the NELF gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165802 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006476 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ Kramer PR, Wray S (Jul 2000). "Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons". Genes & Development. 14 (14): 1824–34. doi:10.1101/gad.14.14.1824. PMC 316793. PMID 10898796.
^ "Entrez Gene: NELF nasal embryonic LHRH factor".

Further reading

Miura K, Acierno JS, Seminara SB (2004). "Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH)". Journal of Human Genetics. 49 (5): 265–8. doi:10.1007/s10038-004-0137-4. PMID 15362570.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

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