Naked cuticle 1

Naked cuticle 1 (NKD1) is a human gene that encodes the protein Nkd1, a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway.[1][2][3] Insects typically have a single Nkd gene, whereas there are two Nkd genes, Nkd1 and Nkd2, in most vertebrates studied to date (zebrafish appear to have additional homologous genes such as Nkd3).[4][5] Nkd1 binds to the Dishevelled (Dvl) family of proteins (DVL1, DVL2, DVL3). Specific truncating NKD1 mutations identified in DNA mismatch repair deficient colon cancer that disrupt Nkd1/Dvl binding implicate these mutations as a cause of increased Wnt signaling in a subset of human colon cancers, the majority of which have increased Wnt signaling due to mutations the adenomatous polyposis coli (APC), AXIN2, or rarely the beta-catenin genes.[6]

Sources

  1. ^ Wharton KA Jr, Zimmermann G, Rousset R, Scott MP. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol. 2001 Jun 1;234(1):93-106. PMID 11356022
  2. ^ Yan D, Wallingford JB, Sun TQ, Nelson AM, Sakanaka C, Reinhard C, Harland RM, Fantl WJ, Williams LT. Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3802-7. PMID 11274398
  3. ^ Katoh M. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. Int J Oncol. 2001 Nov;19(5):963-9. PMID 11604995
  4. ^ Van Raay TJ, Coffey RJ, Solnica-Krezel L. Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol. 2007 Sep 15;309(2):151-68. Epub 2007 Apr 21. PMID 17689523
  5. ^ Schneider I, Schneider PN, Derry SW, Lin S, Barton LJ, Westfall T, Slusarski DC. Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol. 2010 Dec 1;348(1):22-33. Epub 2010 Sep 19. PMID 20858476
  6. ^ Guo J, Cagatay T, Zhou G, Chan CC, Blythe S, Suyama K, Zheng L, Pan K, Qian C, Hamelin R, Thibodeau SN, Klein PS, Wharton KA, Liu W. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One. 2009 Nov 24;4(11):e7982.PMID 19956716

Read other articles:

Nicola Stefanini

Nicola Stefanini Informazioni personali Arbitro di Calcio Sezione Prato Professione Consulente Attività nazionale Anni Campionato Ruolo 2004-20052005-2011 Serie BSerie A e B ArbitroArbitro Premi Anno Premio 2014 Arbitro benemerito Nicola Stefanini (Firenze, 22 gennaio 1975) è un ex arbitro di calcio italiano. In tutte le partite dirette da lui in Serie A, una sola volta c'è stata una vittoria esterna.[1] Carriera Stefanini viene dalla sezione di Prato. Dopo aver totalizzato 37 pre...

 

Vittorio Sentimenti

Vittorio Sentimenti Sentimenti III alla Juventus negli anni 1940 Nazionalità  Italia Altezza 166 cm Peso 70 kg Calcio Ruolo Allenatore (ex centrocampista) Termine carriera 1959 - giocatore 1962 - allenatore Carriera Giovanili 1933-1936 Modena Squadre di club1 1933-1941 Modena124 (59)[1]1941-1949 Juventus210 (62)1949-1952 Lazio75 (9)1952-1956 Torino88 (8)1956-1957 Modena11 (0)1958-1959 Aosta5 (0) Carriera da allenatore 1958-1962 Aosta[...

 

Reece James (pemain sepak bola, lahir 1993)

Reece James James bermain untuk Wigan Athletic pada 2018Informasi pribadiNama lengkap Reece James[1]Tanggal lahir 7 November 1993 (umur 30)Tempat lahir Bacup, Lancashire, InggrisTinggi 1,82 m (5 ft 11+1⁄2 in)Posisi bermain BekInformasi klubKlub saat ini Sheffield WednesdayNomor 33Karier junior Rossendale United Blackburn Rovers Preston North End2012–2013 Manchester UnitedKarier senior*Tahun Tim Tampil (Gol)2013–2015 Manchester United 0 (0)2013 → Carlis...

Oguni, Yamagata

Oguni 小国町KotaprajaBalai Kota Oguni BenderaEmblemLokasi Oguni di Prefektur YamagataOguniLokasi di JepangKoordinat: 38°03′41.3″N 139°44′36.1″E / 38.061472°N 139.743361°E / 38.061472; 139.743361Koordinat: 38°03′41.3″N 139°44′36.1″E / 38.061472°N 139.743361°E / 38.061472; 139.743361Negara JepangWilayahTōhokuPrefektur YamagataDistrikNishiokitamaPemerintahan • WalikotaYōichi NishinaLuas •...

 

Eduard Clam-Gallas

Eduard Clam-GallasLitograf karya Josef Kriehuber, 1849.Lahir(1805-03-14)14 Maret 1805PrahaMeninggal17 Maret 1891(1891-03-17) (umur 86)WinaPengabdianKekaisaran AustriaLama dinas1823–1866PangkatGeneral der KavallerieKesatuanKavaleriKomandanKorps Angkatan Darat Transilvania Pertama, Korps AD Bohemia PertamaPerang/pertempuranPerang Kemerdekaan Italia Pertama Pertempuran Santa LuciaPertempuran VicenzaPertempuran CustozaRevolusi Hungaria 1848Pertempuran SegesvárPerang Kemerdekaan Itali...

 

Daniel Gimeno Traver

Spanish tennis player This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (April 2017) (Learn how and when to remove this template message) In this Spanish name, the first or paternal surname is Gimeno and the second or maternal family name is Traver. Daniel Gimeno TraverGimeno Traver at the 2018 Wimbledon ChampionshipsCountry (sports) SpainResid...

Visa policy of Svalbard

Policy on permits required to enter Svalbard Politics of Svalbard Svalbard Treaty Svalbard Act Governor Lars Fause Longyearbyen Community Council Visa policy See also Politics of Norway Other countries vte Uniquely, the Norwegian archipelago of Svalbard, located in the High Arctic, is an entirely visa-free zone. However, travelers who have a visa requirement to enter mainland Norway/the Schengen area must have a Schengen visa if they travel via mainland Norway/the Schengen area. This must be ...

 

Structure interne de la Terre

Structure interne de la Terre : 1. Croûte continentale 2. Croûte océanique 3. Manteau supérieur 4. Manteau inférieur (ou Mésosphère) 5. Noyau externe 6. Noyau interne (ou graine terrestre) A. Discontinuité de Mohorovičić B. Discontinuité de Gutenberg C. Discontinuité de Lehmann La structure interne de la Terre est la répartition de l'intérieur de la Terre en enveloppes emboîtées : principalement la croûte, le manteau et le noyau, selon le modèle géologique actuel,...

 

The Most Deadly Game

American television series (1970–71) The Most Deadly GameGeorge Maharis, Yvette Mimieux and Ralph Bellamy in a promotional photoGenreDramaCreated byMorton S. FineDavid FriedkinWritten byMorton S. FineDavid FriedkinBernard C. SchoenfeldDirk Wayne SummersDirected byDavid FriedkinLee MaddenStarringRalph BellamyGeorge MaharisYvette MimieuxCountry of originUnited StatesOriginal languageEnglishNo. of seasons1No. of episodes12ProductionExecutive producersMorton S. FineDavid FriedkinAaron SpellingP...

Obywatelstwo

Ceremonia nadania obywatelstwa amerykańskiego Obywatelstwo (ang. citizenship, fr. citoyenneté, niem. Staatsbürgerschaft, ros. гражданство) – przynależność osoby do określonego państwa, na mocy której jednostka ma określone prawa i obowiązki wobec państwa, a państwo – analogicznie – ma obowiązki i prawa wobec jednostki[1]. Określenie spraw związanych z obywatelstwem, a w szczególności sposobów jego nabycia i ewentualnie także utraty, nal...

 

SDN Cipinang 04 Petang

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada Januari 2023. SDN Cipinang 04 PetangSekolah Dasar Negeri Cipinang 04 PetangInformasiJenisNegeriNomor Statistik Sekolah101016402044Nomor Pokok Sekolah Nasional20104336Jumlah siswa358 2010StatusAktifAlamatLokasiJln. Cipinang Timur III / 3, Jakarta Timur, DKI Jaka...

 

Canute IV of Denmark

11th-century King of Denmark Not to be confused with Canute Lavard. Canute IVLegendary painting of the death of Canute IV of Denmark in the Church of Saint AlbanusKing of DenmarkReign1080–1086PredecessorHarald IIISuccessorOlaf IBornc. 1042[1]Died10 July 1086St. Alban's Priory, OdenseBurialSt. Canute's Cathedral, OdenseSpouseAdela of FlandersIssueCharles I, Count of FlandersCecilia KnutsdatterIngegerd KnutsdatterHouseEstridsenFatherSweyn II of DenmarkReligionRoman Catholicism Canute ...

Texoma

For the similarly named towns between the Oklahoma and Texas panhandles, see Texhoma (disambiguation). RegionTexomaRegionLake TexomaMap of Texoma RegionCountry United StatesState Oklahoma TexasLargest cityShermanArea • Total14,961 km2 (5,776 sq mi) • Land14,396 km2 (5,558 sq mi) • Water565 km2 (218 sq mi)  3.8%Population (2010) • Total319,455 • Density21/km2 (55/sq...

 

الشرق الأدنى

الشرق الأدنىمعلومات عامةجزء من The Near and Middle East (en) القارة آسيا الإحداثيات 32°48′N 35°36′E / 32.8°N 35.6°E / 32.8; 35.6 يدرسه دراسات الشرق الأدنى لديه جزء أو أجزاء تركياسوريالبنان تعديل - تعديل مصدري - تعديل ويكي بيانات الشرق الأدنى الشرق الأدنى أو الشرق القريب مصطلح يستخدمه عل�...

 

Grasshopper Club Zúrich

Grasshoppers Datos generalesNombre Grasshopper-Club ZürichApodo(s) GrasshoppersGCZFundación 1 de septiembre de 1886 (137 años)Propietario(s) Los Angeles FCPresidente Stacy JohnsDirector deportivo Stephan SchwarzEntrenador Marco SchällibaumInstalacionesEstadio LetzigrundCapacidad 26.000Ubicación Zúrich, SuizaInauguración 22 de febrero de 1925 (99 años)Uniforme Titular Alternativo Última temporadaLiga Superliga de Suiza(2023-24) 11.Títulos 27 (por última vez en 2002-03...

Ghana ai Giochi della XXV Olimpiade

Ghana ai Giochi della XXV OlimpiadeBarcellona 1992 Codice CIOGHA Comitato nazionaleComitato Olimpico Ghanese Atleti partecipanti37 in 4 discipline Di cui uomini/donne35 - 2 Medagliere Posizione 54ª 0 0 1 1 Cronologia olimpica (sommario)Giochi olimpici estivi 1952* · 1956 · 1960 · 1964 · 1968 · 1972 · 1976 · 1980 · 1984 · 1988 · 1992 · 1996 · 2000 · 2004 · 2008 · 2012 · 2016 · ...

 

Renée d'Autriche-Teschen

Renée de TeschenTitre de noblessePrincesseBiographieNaissance 2 janvier 1888PulaDécès 16 mai 1935 (à 47 ans)BaliceNationalité vénitienneFamille Habsbourg-LorrainePère Charles Étienne de TeschenMère Marie-Thérèse de Habsbourg-ToscaneFratrie Eléonore de TeschenCharles Albert de Habsbourg-AltenbourgMathilde de HabsbourgLéon Charles de Habsbourg-LorraineGuillaume François de Habsbourg-LorraineConjoint Jérôme Radziwill (à partir de 1909)Enfants Princess Maria-Teresa Radziwill...

 

India ai Giochi olimpici

India ai Giochi olimpici Codice CIOIND Comitato nazionaleComitato Olimpico Indiano Cronologia olimpicaGiochi olimpici estivi 1900 · 1904 · 1908 · 1912 · 1920 · 1924 · 1928 · 1932 · 1936 · 1948 · 1952 · 1956 · 1960 · 1964 · 1968 · 1972 · 1976 · 1980 · 1984 · 1988 · 1992 · 1996 · 2000 · 2004 · 2008 · 2012 · 2016 · 2020 · 2024 Gio...

Battle of Walcourt

1689 battle of the Nine Years' War Battle of WalcourtPart of the Nine Years' WarBattle of Walcourt 1689Date25 August 1689[1]LocationWalcourt, Spanish Netherlands(Present-day Belgium)50°15′0″N 04°25′0″E / 50.25000°N 4.41667°E / 50.25000; 4.41667Result Allied victoryBelligerents  Dutch Republic England Scotland Holy Roman Empire Spain  FranceCommanders and leaders Prince of Waldeck Lord of Slangenburg Aylva Duke of Marlbo...

 

Burmese–Siamese War (1775–1776)

War between the Konbaung dynasty of Burma and Thonburi Kingdom of Siam Burmese–Siamese War (1775–1776)Part of the Burmese–Siamese warsMap of Maha Thiha Thura's Invasion of Siam in 1775 – 1776. Green represents Burmese army routes. Red represents Siamese army routes.DateOctober 1775 – August 1776LocationHua Mueang Nuea or Northern Siam, Central Siam and Lan NaResult Siamese pyrrhic victory; depopulation of Northern Cities and destruction of PhitsanulokBelligerents  Konbaung dyna...