NOXA1

NOXA1
Identifiers
Aliases	NOXA1, NY-CO-31, SDCCAG31, p51NOX, NADPH oxidase activator 1
External IDs	OMIM: 611255; MGI: 2449980; GeneCards: NOXA1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,434,406 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	24,985,161 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; mucosa of transverse colon; ; right uterine tube; ; right frontal lobe; ; anterior pituitary; ; Brodmann area 9; ; nucleus accumbens; ; body of pancreas; ; right hemisphere of cerebellum; ; cingulate gyrus;
	Top expressed in
	ileum; ; colon; ; duodenum; ; jejunum; ; stomach; ; embryo; ; embryo; ; uterus; ; lung; ; liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; enzyme binding; superoxide-generating NADPH oxidase activator activity; protein binding;
Cellular component	cytoplasm; cytosol; plasma membrane; membrane; NADPH oxidase complex;
Biological process	regulation of respiratory burst; superoxide metabolic process; regulation of hydrogen peroxide metabolic process; positive regulation of catalytic activity; superoxide anion generation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10811
	241275
	ENSG00000188747
	ENSMUSG00000036805
	Q86UR1
	Q8CJ00
	NM_001256067; NM_001256068; NM_006647
	NM_001163626; NM_172204
	NP_001242996; NP_001242997; NP_006638
	NP_001157098; NP_757341
	Wikidata
View/Edit Human	View/Edit Mouse

NADPH oxidase activator 1 is an enzyme that in humans is encoded by the NOXA1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188747 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036805 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
^ "Entrez Gene: NOXA1 NADPH oxidase activator 1".

Opitz N, Drummond GR, Selemidis S, Meurer S, Schmidt HH (Jan 2007). "The 'A's and 'O's of NADPH oxidase regulation: a commentary on "Subcellular localization and function of alternatively spliced Noxo1 isoforms"". Free Radical Biology & Medicine. 42 (2): 175–9. doi:10.1016/j.freeradbiomed.2006.11.003. PMID 17189823.
Kim JS, Diebold BA, Babior BM, Knaus UG, Bokoch GM (Nov 2007). "Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding". The Journal of Biological Chemistry. 282 (48): 34787–800. doi:10.1074/jbc.M704754200. PMID 17913709.
Valente AJ, El Jamali A, Epperson TK, Gamez MJ, Pearson DW, Clark RA (Aug 2007). "NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain". Free Radical Biology & Medicine. 43 (3): 384–96. doi:10.1016/j.freeradbiomed.2007.04.022. PMID 17602954.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, Nunoi H, Sumimoto H (Jul 2003). "Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases". The Journal of Biological Chemistry. 278 (27): 25234–46. doi:10.1074/jbc.M212856200. PMC 4358237. PMID 12716910.
Geiszt M, Lekstrom K, Witta J, Leto TL (May 2003). "Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells". The Journal of Biological Chemistry. 278 (22): 20006–12. doi:10.1074/jbc.M301289200. PMID 12657628.
Bánfi B, Clark RA, Steger K, Krause KH (Feb 2003). "Two novel proteins activate superoxide generation by the NADPH oxidase NOX1". The Journal of Biological Chemistry. 278 (6): 3510–3. doi:10.1074/jbc.C200613200. PMID 12473664.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188747 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036805 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9610721-5] Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.

[entrez-6] "Entrez Gene: NOXA1 NADPH oxidase activator 1".

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NOXA1

References

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