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NLRC3
Identifiers
Aliases	NLRC3, CLR16.2, NOD3, NLR family, CARD domain containing 3, NLR family CARD domain containing 3
External IDs	OMIM: 615648; MGI: 2444070; HomoloGene: 18720; GeneCards: NLRC3; OMA:NLRC3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,577,403 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	3,794,496 bp
RNA expression pattern
	Top expressed in
	thymus; ; granulocyte; ; mucosa of ileum; ; blood; ; lymph node; ; endothelial cell; ; spleen; ; appendix; ; epithelium of nasopharynx; ; tonsil;
	Top expressed in
	mesenteric lymph nodes; ; blood; ; thymus; ; soleus muscle; ; spleen; ; lumbar subsegment of spinal cord; ; stroma of bone marrow; ; submandibular gland; ; subcutaneous adipose tissue; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATP binding; protein binding; phosphatidylinositol 3-kinase regulatory subunit binding; molecular function;
Cellular component	cytoplasm; microtubule organizing center; cytosol; perinuclear region of cytoplasm;
Biological process	negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; I-kappaB kinase/NF-kappaB signaling; negative regulation of NF-kappaB transcription factor activity; T cell activation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of interferon-alpha production; negative regulation of interferon-beta production; negative regulation of innate immune response; negative regulation of fibroblast proliferation; negative regulation of epithelial cell proliferation; negative regulation of inflammatory response; negative regulation of cytokine production involved in inflammatory response; negative regulation of NLRP3 inflammasome complex assembly; negative regulation of NIK/NF-kappaB signaling; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	197358
	268857
	ENSG00000167984
	ENSMUSG00000049871
	Q7RTR2
	Q5DU56
	NM_178844
	NM_001081280; NM_175547
	NP_849172
	NP_001074749; NP_780756
	Wikidata
View/Edit Human	View/Edit Mouse

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.^[5] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.^[6] NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167984 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049871 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
^ Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
^ Karki R, Man SM, Malireddi RK, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P (December 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. Bibcode:2016Natur.540..583K. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167984 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049871 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18341998-5] Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.

[pmid15705585-6] Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.

[7] Karki R, Man SM, Malireddi RK, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P (December 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. Bibcode:2016Natur.540..583K. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.

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