NLGN3
Neuroligin-3 is a protein that in humans is encoded by the NLGN3 gene.[5][6][7]
This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism spectrum disorders (ASDs).[8][9] Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000196338 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031302 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–310. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
- ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (September 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.
- ^ a b "Entrez Gene: NLGN3 neuroligin 3".
- ^ Uchigashima M, Cheung A, Futai K (2021). "Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction". Frontiers in Molecular Neuroscience. 14 (14) 749164. doi:10.3389/fnmol.2021.749164. PMC 8526735. PMID 34690695.
- ^ Qin L, Liu Z, Guo S, Han Y, Wang X, Ren W, et al. (January 2025). "Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number". Molecular Psychiatry. 30 (1): 84–96. doi:10.1038/s41380-024-02659-6. PMC 11649564. PMID 39003414.
Further reading
- Missler M, Fernandez-Chacon R, Südhof TC (1998). "The making of neurexins". Journal of Neurochemistry. 71 (4): 1339–1347. doi:10.1046/j.1471-4159.1998.71041339.x. PMID 9751164.
- Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ..." Current Biology. 10 (17): R620–3. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
- Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". The Journal of Biological Chemistry. 271 (5): 2676–2682. doi:10.1074/jbc.271.5.2676. PMID 8576240.
- Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, et al. (September 1997). "Binding of neuroligins to PSD-95". Science. 277 (5331). New York, N.Y.: 1511–1515. doi:10.1126/science.277.5331.1511. PMID 9278515.
- Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". The Journal of Biological Chemistry. 272 (41): 26032–26039. doi:10.1074/jbc.272.41.26032. PMID 9325340.
- Gilbert M, Smith J, Roskams AJ, Auld VJ (2001). "Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia". Glia. 34 (3): 151–164. doi:10.1002/glia.1050. PMID 11329178. S2CID 19247385.
- Jamain S, Quach H, Betancur C, Råstam M, Colineaux C, Gillberg IC, et al. (May 2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nature Genetics. 34 (1): 27–29. doi:10.1038/ng1136. PMC 1925054. PMID 12669065.
- Vincent JB, Kolozsvari D, Roberts WS, Bolton PF, Gurling HM, Scherer SW (August 2004). "Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 129B (1): 82–84. doi:10.1002/ajmg.b.30069. PMID 15274046. S2CID 24799609.
- Gauthier J, Bonnel A, St-Onge J, Karemera L, Laurent S, Mottron L, et al. (January 2005). "NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 132B (1): 74–75. doi:10.1002/ajmg.b.30066. PMID 15389766. S2CID 43148256.
- Yan J, Oliveira G, Coutinho A, Yang C, Feng J, Katz C, et al. (April 2005). "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients". Molecular Psychiatry. 10 (4): 329–332. doi:10.1038/sj.mp.4001629. hdl:10400.18/346. PMID 15622415. S2CID 17530049.
- Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2005). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Blasi F, Bacchelli E, Pesaresi G, Carone S, Bailey AJ, Maestrini E (April 2006). "Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 141B (3): 220–221. doi:10.1002/ajmg.b.30287. PMID 16508939. S2CID 42297317.
- Talebizadeh Z, Lam DY, Theodoro MF, Bittel DC, Lushington GH, Butler MG (May 2006). "Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism". Journal of Medical Genetics. 43 (5): e21. doi:10.1136/jmg.2005.036897. PMC 2564526. PMID 16648374.
- Yamakawa H, Oyama S, Mitsuhashi H, Sasagawa N, Uchino S, Kohsaka S, et al. (March 2007). "Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations". Biochemical and Biophysical Research Communications. 355 (1): 41–46. Bibcode:2007BBRC..355...41Y. doi:10.1016/j.bbrc.2007.01.127. PMID 17292328.
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