NISC may refer to:

• No instruction set computing, an architecture designed for efficiency
• National Invitational Softball Championship, an American collegiate sports tournament
• National center of Incident readiness and Strategy for Cybersecurity, Japan's government institute for cybersecurity
• National Information Solutions Cooperative, information technology cooperative for utility and broadband companies

• All pages with titles beginning with NISC
• All pages with titles containing NISC

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