Myrne was founded in 1951 in connection with the construction of granite quarries in the local area. At the time of its founding, it was located in Telmanove Raion, Donetsk Oblast in the Ukrainian SSR. In 1967, Myrne received urban-type settlement status.[1]
In December 2014, during the war in Donbas, separatists loyal to the Donetsk People's Republic, a pro-Russian breakaway state in eastern Ukraine, had seized control of most of Telmanove Raion. As a result of the violence, the Ukrainian government moved the administration building and government of Telmanove Raion from Telmanove to Myrne.[4][5] Telmanove Raion was renamed Boikivske Raion in 2016.[1] In June 2020, Myrne became the center of Myrne settlement hromada within Volnovakha Raion.[6] Boikivske Raion was abolished by the Ukrainian government as an administrative unit in July 2020.[7][8]