Spiegel's best known and most widely used software, "Music Mouse - An Intelligent Instrument" (1986) is for Macintosh, Amiga and Atari computers.[1][2][3] The "intelligentinstrument" name refers to the program's built-in knowledge of chord and scale convention and stylistic constraints.[4] Automating these processes allows the user to focus on other aspects of the music in real time.[5] In addition to improvisations using this software, Spiegel composed several works for "Music Mouse", including Cavis muris in 1986, Three Sonic Spaces in 1989, and Sound Zones in 1990.[6] She continued to update the program through Macintosh OS 9. It remained available until 2021; as of 2023, the website is no longer active and is archived on the Wayback Machine.[3][additional citation(s) needed]