She was born in 1884 in Mecca, Ottoman Empire. Her title at birth was Sharifa of Mecca. She was the elder twin daughter of Amir Nasser Pasha and his wife Dilber Khanum, the younger being Huzaima, Queen consort of Syria and Iraq as wife of Faisal I.
Abdullah went on to take two more wives. He married Princess Suzdil Khanum in 1913 (daughter of 'Ali) and Nahda bint Uman in 1949 (a Sudanese woman), making Musbah his senior wife. On 25 May 1946, Abdullah was proclaimed King of Jordan and Musbah, as his first wife, became Queen of Jordan.