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Route 51
Route information
Maintained by MoDOT
Length	120.811 mi[1] (194.426 km)
Existed	1922–present
Major junctions
South end	AR 139 at the Arkansas state line
Major intersections	Future I-57 / US 60 at Fisk I-55 at Perryville US 61 at Perryville
North end	IL 150 / Great River Road at the Illinois state line
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← US 50 → Route 52

Route 51 is a highway in southeastern Missouri. Its northern terminus is the Illinois state line near Chester, Illinois; its southern terminus is at the Arkansas state line northwest of Piggott, Arkansas. It continues into Illinois as Illinois Route 150 and it continues into Arkansas as Highway 139.

Route 51 is one of the original 1922 state highways and ran from the Mississippi River to Advance.

Route 51A, a branch route, formerly connected Route 51 with Puxico when Route 51 ended at Advance (at Route 25). Route 51A would become part of the main highway when it was re-routed and extended.

This section is empty. You can help by adding to it. (May 2021)

This section is empty. You can help by adding to it. (May 2021)

County	Location	mi[1]	km	Destinations	Notes
Butler	Gillis Bluff Township	0.000	0.000	AR 139 south – Pollard	Continuation into Arkansas
	Qulin	7.354	11.835	Route 53 south – Campbell	Southern end of Route 53 overlap
	Ash Hill Township	10.318	16.605	Route 53 north – Poplar Bluff	Northern end of Route 53 overlap
Stoddard	Duck Creek Township	25.713	41.381	US 60 (Future I-57) – Poplar Bluff, Sikeston
Bollinger	Liberty Township	61.820	99.490	Route 91 south – Advance
	Marble Hill	71.679	115.356	Route 34 west (First Street)	Western end of Route 34 overlap
		72.179	116.161	Route 34 east – Jackson	Eastern end of Route 34 overlap
	Union Township	90.011	144.859	Route 72 – Millersville, Fredericktown
Perry	Perryville	106.127	170.795	I-55 – Cape Girardeau, St. Louis
		108.829	175.143	US 61 (Kingshighway) – Longtown, St. Mary
Mississippi River		120.811	194.426	Chester Bridge; Missouri–Illinois state line
				IL 150 east – Chester	Continuation into Illinois
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

This section is empty. You can help by adding to it. (May 2021)

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