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The Mission League is a high school athletic league that is part of the CIF Southern Section.

• Bishop Alemany High School (Mission Hills)
• Chaminade College Preparatory (West Hills)
• Crespi Carmelite High School (Encino)
• Harvard-Westlake School (Studio City)
• Loyola High School (Los Angeles)
• Notre Dame High School (Sherman Oaks)
• Sierra Canyon School (Chatsworth)
• St. Francis High School (La Cañada)
• Louisville High School (Woodland Hills) (Girls' Sports Only)

• Bishop Amat Memorial High School (La Puente)
• Chaminade College Preparatory (West Hills)
• Junipero Serra High School (Gardena)
• Loyola High School (Los Angeles)
• Notre Dame High School (Sherman Oaks)

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