Sultan Fakhruddin Mobarak Shah conquered Chittagong in 1340 AD and established Muslim rule in this region. During the reign of Sultans Hussain Shah and Nusrat Shah, Paragal Khan and Chhuti Khan were the rulers of this area. Subsequently, Nizam Shah, brother of emperor Sher Shah, was the ruler of this area. Nizampur Pargana is named after Nizam Shah and the whole area of Mirsharai came under the control of this pargana.
From the beginning of the 16th century the region was very rich in Bangla literature. Most of the time between 1580 and 1666, the region was under the control of the Arakanese.
The place within the current Mirsharai thana where Bujurg Umed Khan, son of Subadar Sayesta Khan, landed after crossing the Feni River was named as Bujurg Umedpur. With the conquest of Chittagong by Khan in 1666, the region came permanently under Mughal rule.
Towards the end of British rule in India, the Durgapur and Karerhat areas of Mirsharai were the centres of revolutionary activities of Chittagong. A fierce battle was fought between the freedom fighters (under Captain Wali Ahmed) and the Pak Army near the Fenafuni Bridge on the south of Mirsharai sadar, in which about 100 Pak soldiers were killed. The two sides also fought at places including Shuvapur Bridge, Hinguli Bridge, Aochi Mia Bridge and Mostan Nagar.
As of the 2011 Census of Bangladesh, Mirsharai upazila had 79,545 households and a population of 398,716. 88,008 (22.07%) were under 10 years of age. Mirsharai had an average literacy rate of 55.08%, compared to the national average of 51.8%, and a sex ratio of 1128 females per 1000 males. 31,206 (7.83%) of the population lived in urban areas.[5] Ethnic population was 2,266 (0.57%), of which Tripura were 2,242.[6]
In the 1991 census in Bangladesh, Mirsharai had a population of 325712. Males constituted 49.97% of the population, and females 50.03%. This Upazila's eighteen up population is 160,496. Mirsharai has an average literacy rate of 37.2% (7+ years), and the national average of 32.4% literate.[7][8]
According to Banglapedia, Abu Torab High School, founded in 1914, Mirsharai Government Model Pilot High School (1962), Mithachhara High School (1947), Sarkar Hat N. R. High School (1939), and Zorwarganj Model Multilateral High School (1914) are notable secondary schools.[10]
^"Bangladesh Postal Code". Dhaka: Bangladesh Postal Department under the Department of Posts and Telecommunications of the Ministry of Posts, Telecommunications and Information Technology of the People's Republic of Bangladesh. 20 October 2024.