Beginning his career as a screenwriter and standup comedian,[6] in March 1990 with the March 9 theatrical premiere of his first screenplay, Coupe de Ville, directed by Joe Roth and co-produced by Binder, and his own HBO stand up comedy special, broadcast the following night.
Binder's directorial debut was with his second screenplay, 1992's Crossing the Bridge.
Binder gained further prominence with his 20-episode 2001-02 HBO comedy series, The Mind of the Married Man, which he co-wrote, co-directed and starred in as the central character "Micky Barnes".[7][8] That same year, his independently produced film The Sex Monster won "Best Film" and Binder won "Best Actor" at the 2001 Comedy Arts Festival in Aspen.
Binder's first novel, Keep Calm, a thriller set in the UK, was published in 2016.[10] He directed stand-up comedian Bill Burr's most recent Netflix comedy special Paper Tiger. On October 4, 2020, his five-part documentary series on The Comedy Store, based on the years he spent there and interviews with most of the major alumni of the famous nightclub, aired on Showtime.