The series focuses on the title characters Mike Biggs (Billy Gardell) and Molly Flynn (Melissa McCarthy), a couple who meet at an Overeaters Anonymous meeting in Chicago, Illinois. After Molly, a primary-school teacher, invites police officer Mike to give a talk to her class, they begin dating. Molly lives at home with her mother Joyce (Swoosie Kurtz), and sister Victoria (Katy Mixon). Joyce is in an on-off relationship with widower Vince Moranto (Louis Mustillo), who is often seen at the house. Mike lives alone in an apartment but is regularly kept company by his best friend and partner in the police force Carl McMillan (Reno Wilson). Other prominent characters in the series include Carl's grandmother Rosetta (Cleo King); Mike's mother Peggy (Rondi Reed) and cafe worker Samuel (Nyambi Nyambi). Season one of Mike & Molly consisted of 24 episodes and aired Mondays in the United States at 9.30 p.m. until April 11, 2011, with the final three episodes airing at 9.00 p.m.
The season received mixed reviews from critics, some of whom believed the show was clichéd and re-trod the path of old sitcoms. Some critics questioned the subject matter, with one particularly controversial article from Marie Claire commenting on the idea of two overweight actors playing starring roles. Nevertheless, the series received average ratings of 11.14 million viewers, placing it as the number 35 most watched show of the television season. Melissa McCarthy won the Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series at the 63rd Primetime Emmy Awards for her performance as Molly, and the series was also nominated for a People's Choice Award for Best New Comedy. Mike and Molly was renewed for a second season to premiere in the 2011–12 television season.
Mike struggles with his new diet. At an Over-Eaters Anonymous meeting, Molly sympathizes with Mike and invites him to come speak to her fourth grade class. Later, he appears at her home after a robbery and asks her out on a date. She says yes.
Molly gets a head cold before her first date with Mike. Her mother and sister accidentally both give her medicine and Molly adds wine at dinner. The night ends up being a disaster. Meanwhile, Mike gets fashion advice from Carl and his cousin, Andre (Lamont Thompson), who own a "Big & Tall" store.
Mike gets beat at bowling by Molly, who turns out to be a better bowler and an ungracious winner. He later gets some advice from Carl's grandmother (Cleo King), who tells him that there's nothing sexier in a man than him being honest. Mike then takes Molly again to bowling, and when she strikes again, he kisses her for the first time.
Molly misunderstands Mike's reasoning for not wanting to come inside her house after a date and breaks-up with him. After getting drunk in a bar, Mike reveals that he's ashamed of his own body, and that's the reason why he had been taking things too slow with Molly. After leaving the bar, Mike, Carl, Samuel and the taxi driver, Undugu, go to Molly's house where Mike decides to serenade Molly. When he reaches her window, he tells her why he wasn't ready to take the next step, and that he wants the first time to be very special. However, he passes out while on the ladder and the gang is forced to spend the night at Molly's house.
Mike and Molly take her sister Victoria on a double date with Carl. After a nice dinner, Victoria leaves with Michael Jordan and Molly tells Mike that he is going to get lucky, but a small accident prevents it.
Mike's plans for a romantic night with Molly are interrupted by a call from his mother, Peggy (Rondi Reed) who fakes having chest pains. Peggy is hostile towards Molly because she feels that she will get replaced. Molly explains this to Mike and they sleep together after Mike finds a way to ignore the calls from his mom.
After spending the weekend together, Mike and Molly are ecstatic. To avoid getting too clingy, Molly tries to slow down, but it doesn't help when Mike visits her in the school with a Teddy Bear.
Molly gets mad when a blonde woman named Jill (Rebecca Field), flirts with Mike at their Over-Eaters Anonymous meeting, and Mike introduces Molly to her as his "friend". After a long talk with Carl's grandma, Mike realizes that he is in love with Molly. On the other hand, Molly gets drunk with Victoria and realizes that she is in love with Mike. Joyce starts dating Vince (Louis Mustillo).
Molly feels obliged to invite Mike's mother, Peggy, to spend Thanksgiving in her house after Peggy gives her a hat as a present of goodwill. Mike invites Carl and his grandma and Carl invites Samuel & his 5 roommates. Molly tries to prepare a meal for all the guests, but the turkey is a disaster.
After Carl borrows Mike's apartment for a date night, Mike spends the night with Molly's family, where he bonds with her mother and sister and gets in touch with his feminine side. Joyce & Vince break up, and Mike helps Vince patch things up.
Mike has no idea what to get Molly for their first Christmas as a couple. He runs a lot of ideas through Joyce & Carl, but they reject it all. He is also unable to take the hints Molly gives him. Finally, he ends up buying her expensive jewelry. Molly gets Mike a leather jacket, but has to exchange it for a video game when Mike ends up buying a jacket himself.
13
13
"Mike Goes to the Opera"
James Burrows
Story by : Mark Roberts & Chuck Lorre Teleplay by : Don Foster & Al Higgins
Molly and Peggy fight over who can take better care of Mike when he gets sick on a trip to the opera. They keep driving him back and forth between their houses, without any consideration for Mike's health.
Molly doesn't like that her mother's new boyfriend, Vince, is trying to befriend Mike. When Mike decides to go to a basketball game with Vince & Carl, instead to taking Molly out, she gets mad and tries her best to stop him by being very passive-aggressive. He ends up going anyway and Molly ends up spending time with her sister & mother, who are both high. In the end, Vince proposes to Joyce and she says, yes.
15
15
"Jim Won't Eat"
James Burrows
Story by : Mark Roberts & Don Foster Teleplay by : Al Higgins & Julie Bean
During a dinner at Peggy's place, she informs them that she is having a gallbladder surgery. She asks Mike to drive her to the hospital, where she believes she would die. Peggy offers Mike the grave next to her, but he tells Molly that he wants to be buried next to her, which shocks her and they have a huge fight. Peggy leaves Jim with Molly and she takes him home. When Jim refuses to eat, Victoria takes Jim out for a walk, which changes him completely. Peggy pulls through and Mike & Molly make-up.
Mike orders a special cake for Valentine's day and ends up meeting the baker, who turns out to be Molly's ex-fiancé, Kyle (Robert Gant). He gets very upset because Molly never mentioned being engaged, but later discovers that Kyle is gay. Vince & Joyce go to an adult motel for their first Valentine's Day.
17
17
"Joyce & Vince and Peaches & Herb"
James Burrows
Story by : Mark Roberts & Don Foster Teleplay by : Mark Gross & Al Higgins
Molly wants Mike to take her out more often, while Mike decides the couch is his best friend. On Carl's suggestion, Mike decides to make Molly dinner and just stay home, but Molly is bored and decides to hit the town with her sister, Victoria. Mike visits his mom who tells him about her relationship with his dad, which was boring. Mike finally tracks down Molly & goes to the club. Vince takes Joyce out to see Peaches & Herb and has sex with her on the stairs.
18
18
"Mike's Feet"
James Burrows
Story by : Mark Roberts & Don Foster Teleplay by : Mark Gross & Al Higgins
Mike and Carl get on each other's nerves after working too many double shifts together and start bickering continuously. He rambles on and on about Carl while eating with Molly and ruins the dinner. Mike & Carl bicker while Mike is driving & they end up in an accident and later ends up ruining his & Molly's weekend getaway. Molly then helps Carl & Mike mend their fight.
19
19
"Peggy Shaves Her Legs"
James Burrows
Story by : Mark Roberts & Don Foster Teleplay by : Julie Bean & Carla Filisha
Peggy is unusually nice to Molly and decides to have lunch with her. Mike worries that his mom may tell stories that embarrass him. During lunch Peggy tells Molly that she has been asked out on a date and asks her to keep it from Mike, but Molly tells Mike anyway. Molly, Joyce & Victoria helps Peggy get ready, and Mike follows her to keep a check on her.
20
20
"Opening Day"
James Burrows
Story by : Mark Roberts & Jim Patterson Teleplay by : Don Foster & Al Higgins
When Molly mentions going to Chicago Cubs games with her dad, Mike breaks tradition and invites Molly to join Carl and him to the opening day game. As only two seats are in the front, they use round robin and keep changing their seats. During the game, Molly gets very emotional, Mike is trying his best to keep his diet and Carl is unhappy that he did not have a good relationship with his father.
21
21
"Samuel Gets Fired"
James Burrows
Story by : Mark Roberts & Don Foster Teleplay by : Al Higgins & Julie Bean
Thanks to Carl's interference, Samuel is fired from his job at the restaurant and Mike & Carl are asked to start paying for their meals. Samuel moves in with Mike, as he has no money to pay rent and Mike moves in with Molly. Samuel accompanies Mike to Molly's house for dinner. Samuel's boss hires his own wife to replace Samuel. Samuel starts re-decorating and using Mike's house for entertaining women. Finally, Mike pays Samuel's raise, Abe (Keone Young), and gets him the job back.
22
22
"Cigar Talk"
James Burrows
Story by : Mark Roberts & Don Foster & Chuck Lorre Teleplay by : Al Higgins & Mark Gross
Joyce wants to take Vince along as her date to her high school reunion, prompting Vince to reveal he never finished high school to Mike, over a cigar. Mike tells Molly that Vince has a secret and she assumes that Vince is cheating and tells Joyce. Meanwhile, Mike helps Vince to study for a GED test. The girls are upset with Vince until he tells them the truth, and Molly helps him study.
23
23
"Victoria's Birthday"
James Burrows
Story by : Mark Roberts & Don Foster & Chuck Lorre Teleplay by : Julie Bean & Carla Filisha & Jim Patterson
Victoria turns 30 and is not happy about it. Molly tries to help her and ends up convincing Victoria to have a baby. Mike then tries to talk to her and she ends up deciding to join the army. Finally, Carl asks her to join his church. In the subplots, Vince & Mike want to watch Godfather, but Molly keeps interrupting. Mike & Molly struggle with their new diet.
24
24
"Peggy's New Beau"
James Burrows
Story by : Mark Roberts & Don Foster & Chuck Lorre Teleplay by : Al Higgins & Mark Gross
Mike & Molly meet Peggy's new "friend from church", Dennis (William Sanderson). They instantly like him, but when he brings up wedding bells, they feel a bit pressured. After a talk with Carl's grandma, Mike decides to propose to Molly. She says yes.