PROFILPELAJAR.COM

MIR4521
Identifiers
Aliases	MIR4521, mir-4521, microRNA 4521
External IDs	GeneCards: MIR4521; OMA:MIR4521 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,187,004 bp
RNA expression pattern
	Top expressed in
	blood; ; sural nerve; ; bone marrow; ; Descending thoracic aorta; ; monocyte; ; muscle of leg; ; gastrocnemius muscle; ; endometrium; ; Achilles tendon; ; lymph node;
	n/a
	More reference expression data
	n/a
Orthologs
	100616406
	n/a
	ENSG00000283160
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

MicroRNA 4521 is a micro RNA that in humans is encoded by the MIR4521 gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

miR-4521 has been shown to have decreased expression in various cancers, including breast cancer and lung cancer. In gastric carcinoma, miR-4521 has been reported to inhibit EMT and metastasis.^[4]