She is the author of the nonfiction books Apply Within: Stories of career sabotage[3] and Last Bets: A true story of gambling, morality and the law.[4]
She has also worked as a journalist, including writing a column for The Monthly on current affairs, and features and book reviews for Fairfax Media.[1]
Along with Marieke Hardy, she co-curated and hosted the popular international monthly literary event 'Women of Letters.'[5] At the events, female writers and performers read letters they have written on set monthly themes.[6] Started in Melbourne in 2010, the event now includes "shows across the United States and Britain, along with new Men of Letters shows and People of Letters shows – plus shows in Sydney, Tasmania and Perth."[7] Featured readers have included Martha Wainwright, Edie Falco and Moby.[5]
In December 2016, McGuire moved to Sydney to take up her appointment as Artistic Director of the Sydney Writers' Festival.[8][2][9] In July 2020, the Melbourne Writers Festival announced McGuire's appointment as their new Artistic Director, to begin after the completion of their digital program in August 2020.[10][11]