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Michael or Mike O'Brien may refer to:

Politicians

Michael O'Brien (Fianna Fáil politician), Irish former councillor and mayor of Clonmel
Michael O'Brien (Ohio politician) (born 1955), American politician in the state of Ohio
Michael O'Brien (South Australian politician) (born 1949), Australian Labor Party member of the South Australian House of Assembly, 2002–present
Micheal O'Brien (Canadian politician), Progressive Conservative Party of Canada candidate for the Canadian House of Commons
Michael O'Brien (Victorian politician) (born 1971), Liberal Party of Australia member of the Victorian Legislative Assembly, 2006–present
Michael H. O'Brien (1954–2018), American politician in the commonwealth of Pennsylvania
Michael J. O'Brien (born 1939), American politician in the state of Iowa
Michael John O'Brien (1851–1940), Canadian politician, railway builder, industrialist and philanthropist
Mike O'Brien (British politician) (born 1954), United Kingdom Labour Party politician
Mike O'Brien (Canadian politician), mayor of Fredericton, New Brunswick
Mike O'Brien (Seattle politician) (born 1968), American politician

Michael O'Brien (Australian rules footballer) (born 1980), West Coast Eagles
Michael O'Brien (fencer) (born 1969), Irish fencer
Michael O'Brien (hurling manager) (1933–2014), Irish Catholic priest and former hurling manager
Michael O'Brien (Irish sportsman), Irish association footballer, Gaelic footballer and cricketer in the 1920s
Mike O'Brien (swimmer) (born 1965), American swimmer
Micheál O'Brien (1923–2015), Irish Gaelic footballer and hurler
Mike O'Brien (American football) (born 1956), American football player
Mike O'Brien (hurler) (born 1978), Irish hurler

Michael O'Brien (bishop) (1876–1952), Irish Roman Catholic bishop
Michael O'Brien (American poet) (born 1939), American poet
Michael O'Brien (Canadian author) (born 1948), Canadian author
Michael O'Brien (game designer), Australian game designer
Michael O'Brien (historian) (1948–2015), American historian
Michael O'Brien (unionist) (born 1949 or 1950), American labor union leader
Michael O'Brien (musician) (born 1964), American musician
Michael O'Brien (photographer) (born 1950), American photographer
Michael K. O'Brien, visual effects artist
Mike O'Brien (actor) (born 1976), American writer and performer on Saturday Night Live
Mike O'Brien (game developer), co-founder, ArenaNet; game designer and programmer

Guardsman (Michael O'Brien), a fictional character in the Iron Man comics
Michael O'Brien, a fictional engineer character in the 1940 Christmas film Beyond Tomorrow