Melinda Hsu graduated from Harvard College and then earned a MFA in Film from Columbia University. Prior to her work as a staff writer on Still Life (a one-hour drama for the FOX network), she worked as a story analyst for producers, agents, and writers nationwide.
She began working in television as a writer for the first season of Medium in 2005. She wrote the episodes "Jump Start" and "Being Mrs. O'Leary's Cow". She became a story editor for the second season later in 2005 and wrote the episode "Dead Aim". She left the series at the end of the second season in 2006 having written three episodes.
She became an executive story editor for the series Vanished in 2006 and wrote the episode "The New World". Vanished was canceled after thirteen episodes. Hsu moved on to become an executive story editor and writer for the series Women's Murder Club in 2007. She co-wrote the story and the teleplay for the episode "The Past Comes Back to Haunt You" (story with Sherry Carnes, teleplay with Robert Nathan) and wrote the episode "And the Truth Will (Sometimes) Set You Free". The series was cancelled after the first season.