Nitzan became mayor of Rishon LeZion in 1983 and was re-elected four times. In November 2008, he lost the municipal elections to Dov Zur.[1] After his defeat, Nitzan announced that he would run in the Kadima party primaries and vie for a seat in the Knesset in the 2009 elections.[2] However, he later left the party to support Likud as he was unhappy with the behaviour of party leader Tzipi Livni. Kadima claimed Nitzan quit because the party refused to cover his campaign debts.[3]
Nitzan served as acting mayor of Lod in 2011–2013.[4] During his tenure, the crime rate dropped, the municipality organized a sulha, a traditional Arab conciliatory meeting between two feuding families, and the budget was balanced.[5]