Uncle: Mei Sizu, Marquis of Runan (汝南侯 梅思祖; d. 1382), the younger brother of Mei Yin's father
Cousin: Mei Yi (梅義), Military Commissioner-in-chief of Liaodong, son of Mei Sizu. He was involved in the Hu Weiyong case and his family was persecuted.
Wife: Princess Ningguo (寧國公主; 1364–1434), the second daughter of the Hongwu Emperor and the eldest daughter of Empress Ma. She was also the favourite sister of the Yongle Emperor.[3]
Sons:
Mei Shunchang (梅順昌), Vice Commissioner-in-chief of the Center[4]
Mei Yongzhen (梅永貞), Commander of Xiaoling Guard
Mei Jingfu (梅景福), Commander of the Standard-bearer Guard[4]
Great-great-grandson: Mei Chun (梅純), Vice Regent of the Central Capital