"Medicine" is the first promo single of American hip hoprecording artistPlies' fourth studio album, Goon Affiliated. The track is absent from the retail versions for unknown reasons, but is on the Amazon deluxe version. The hip hop track features American singer-songwriter Keri Hilson. There are two versions, one with a more radio friendly, slow beat and one with a more club beat.
The original version of the song was by Three 6 Mafia ft. Gucci Mane & Keri Hilson under the same title. The tempo is somewhat slower in that version.
A music video was shot for the song and premiered on January 14, 2010. It takes place in a hospital where Keri Hilson plays a nurse and Plies is the doctor which makes reference to the song. Myammee from VH1 also makes a cameo in the beginning of the video.
