Maysville was probably named for the May family, who were early settlers of the area.[3] The area was once cotton and corn fields, but with the high-tech boom created by NASAMarshall Space Flight Center, and the Missile Defense Agency, the area has transformed into a grouping of subdivisions such as Cooper Estates and Maysville Estates. A post office operated under the name Maysville from 1850 to 1955.[4]