Route 107 begins in Revere at an interchange with Route 16 (the Revere Beach Parkway) just north of the Chelsea town line. The route serves as Broadway, the main street through the city of Revere. The route intersects Route 60 at Brown Circle. From the rotary, the route becomes a limited access highway through the Rumney Marsh Reservation as the Salem Turnpike, entering Saugus over the Pines River. It continues as an expressway for roughly 2.2 miles until just before the Saugus River, where the road enters Lynn via the Belden Bly Bridge.
In Lynn, Route 107 becomes Western Avenue, immediately passing the General Electric River Works. The route continues through the city, passing the western end of Lynn Commons before intersecting Route 129. The route passes Bayridge Hospital and Fraser Field before meeting Route 129A, running concurrently for approximately half a mile eastward until Route 129A turns southward. The concurrency with Route 129A was the original alignment of Route 129 prior to the creation of Route 129A in 1996. The route crosses Floating Bridge Pond, so named because the original roadway was an actual floating bridge, before entering the city of Salem.
Route 107 in Salem travels as Highland Avenue, heading uphill and passing the area of Salem Hospital/North Shore Medical Center before the road meets Boston Street at Essex Street. Route 107 turns west along Boston Street before turning northward again along Bridge Street, not far from Gallows Hill Park, site of the hanging during the Salem witch trials. The route travels along the North River before having an interchange with Route 114. The route then passes the Salem MBTA station, and becomes a limited access route once again as the Bridge Street Bypass. Completed in 2008, this super two section of Route 107 keeps traffic from the MBTA station and other areas of Salem off the busy city streets, following just west of the MBTA commuter tracks before ending at Route 1A at the Salem end of the Veterans Memorial Bridge over the Danvers River.
Prior to the completion of the Bridge Street Bypass, Route 107's northern end was at the intersection of Bridge Street and Winter Street, north of Salem Commons, where Route 1A turns from Winter Street to Bridge Street northbound. Because of the moving of the northern end, the route was lengthened from 11.29 miles (18.17 km) to 11.9 miles (19.2 km).[2]