A career breakthrough came in 2012 with Weatherford's Bakersfield Project exhibition at the Todd Madigan Gallery at California State University at Bakersfield where she was an artist in residence. The Bakersfield paintings marked the first time she incorporated illuminated neon light tubes into her abstract paintings.[12][16] The series was inspired by the colourful neon signs she saw on old restaurant and factory buildings while driving around Bakersfield.[17]
Weatherford used neon in the Bakersfield Project and later series of paintings, such as Manhattan (2013), Los Angeles (2014) and Train Yard (2016–2020) to recreate the sensations of specific places or moments.[17] In an interview for Gagosian Quarterly she once said, ‘I try to depict or deliver not only a visual translation of a place in time, but with that, the scent, the sound, and the feeling. Is it chilly? Is it hot? Is there a clanging sound?’[18]
Her work was included in the exhibitions Variations: Conversations in and Around Abstract Painting at the Los Angeles County Museum of Art and The Forever Now: Contemporary Painting in an Atemporal World at the Museum of Modern Art in New York in 2014. That same year she received the $25,000 Artist Award from the Artists' Legacy Foundation founded by Viola Frey.[19] Examples of Weatherford's abstract paintings incorporating neon lights are held by the Museum of Modern Art, the Hirshhorn Museum, and the Hammer Museum.[20][21][22] Another of her neon paintings, Past Sunset (2015), was shown at the National Museum of Women in the Arts in the 2016 exhibition NO MAN'S LAND: Women Artists from the Rubell Family Collection.[23] Three examples of her early work combining acrylic, ink and screen print are held by the Brooklyn Museum: Madame Butterfly (1989), Violetta (1991), and First Riddle (1991).[24]
In 2016, Mary Weatherford joined The Metropolitan Museum of Art's The Artist Project, where contemporary artists engage online with The Met's historical collections connecting contemporary art with artistic traditions across different eras.[25][26]