Between 1960 and 1962, D'Imperio created the TEMAC (Text Macro Compiler) language for processing text.[5] From 1987 to 2006, she was a frequent contributor to North American Breeding Bird Survey reports.[6]
She was introduced to the problem of the Voynich Manuscript by John Tiltman in 1975. She wrote several books and journal articles about the manuscript. These include The Voynich Manuscript: An Elegant Enigma, The Voynich Manuscript: A Scholarly Mystery, and An Application of Cluster Analysis and Multiple Scaling to the Question of "Hands" and "Languages" in the Voynich Manuscript.
According to a 1976 introduction by Vera Filby: "Her career has been with the government since 1951. She was a linguist and cryptanalyst, but thought of herself mainly as a computer programmer".[7]
D'Imperio, Mary Evelyn (1955). A survey of decipherment (M.A. in Linguistics). Graduate School of Arts and Sciences, University of Pennsylvania.
D'Imperio, Mary E. (1956). Tamil Grammar Notes. Washington, D.C.: Foreign Service Institute, Department of State.
D'Imperio, M. E. (1965). "TEMAC (Text Macro Compiler): A Machine Language for Processing Text". NSA Technical Journal. X (3).
D'Imperio, M. E. (1969). "Data Structures and their representation in storage". Annual Review in Automatic Programming. 5: 1–75. doi:10.1016/0066-4138(69)90036-6.