The Chicago Bears selected Wright in the third round (75th overall pick) of the 2010 NFL draft.[8] He was predicted to be a future starter by former Bears general manager Jerry Angelo.[9] During his rookie season, Wright played in eleven of sixteen regular season games. He recorded his first career interception in 2011 off a Michael Vick pass against the Philadelphia Eagles, when a pass by Vick squirted through linebacker Lance Briggs's hands into Wright, who was able to return the ball 39 yards.[10] A week later against the Detroit Lions, Wright intercepted a Matthew Stafford lob and returned it 24 yards for a touchdown, which was the first pick-six of his career.[11]
In the 2012 season Wright started all 16 games for the Bears at Strong Safety, recording four interceptions along with 52 tackles for the year. During the Week 3 match up against the St. Louis Rams he returned an interception 45 yards for a defensive touchdown.
Tampa Bay Buccaneers
On April 4, 2014, Wright agreed to a one-year contract with the Tampa Bay Buccaneers, reuniting with his former Bears head coach Lovie Smith.[12] Wright was cut by the Buccaneers on August 30, 2014. Wright rejoined the team on September 3, 2014.
Wright re-signed with the Buccaneers on March 7, 2015.[13] On December 30, 2015, Wright was placed on injured reserve.[14]
On August 28, 2016, Wright was waived by the Buccaneers.[15] He was re-signed by the Buccaneers on November 29, 2016.[16] He was released again on December 13, 2016.[17]
On May 8, 2020, Wright announced his first book called Major Pain: Confessions Of A Smash-Mouth Safety.[19]
In 2021 Major Wright launched the Wright Way Charities to provide support and hope to single mothers in Ft. Lauderdale, FL. WWC assists with finding jobs, housing, insurance and provides financial literacy teachings.
In 2022, Wright wrote his second book, Good Deed Tuesday, a modern day superhero who gets his superpowers by helping others. Written to inspire kindness in 5-10 year olds, Wright created a school program to bring the positive lessons to the classroom. Recognized as a gifted communicator, Wright holds engaging assemblies in elementary schools to promote kindness and empathy to peers, teachers and family members.
Wright resides in the Ft. Lauderdale area and continues to hold community building events in the neighborhood he grew up in, recognizing the need for positive role models in underserved areas.