In June 2013, Hughes qualified for the U.S. Open, winning a playoff at his sectional qualifying site. He won his first professional tournament at the 2013 Cape Breton Celtic Classic on PGA Tour Canada. He would go on to win the 2013 PGA Tour Canada Order of Merit and earn a Web.com Tour card for 2014, fully exempt as the money leader. Hughes made seven cuts in twenty events, finishing well outside retaining any status. After spending the 2015 season on PGA Tour Canada, he earned Web.com Tour status for 2016 through Q School. In August 2016, he won the Price Cutter Charity Championship en route to graduating to the PGA Tour for the 2016–17 season.
In March 2020, Hughes finished second at The Honda Classic finishing one stroke behind champion Im Sung-jae.[6] He shot 66-66 on the weekend. In June he finished tied for third place in the Travelers Championship and entered the top 100 in the world rankings for the first time.
Hughes held the lead after the third round at the 2021 U.S. Open but finished T15. He was also in contention at the 2021 Open Championship, eventually finishing T6 and recording the best ever finish for a Canadian at The Open Championship.[7]
QF, R16, R32, R64 = Round in which player lost in match play
NT = No tournament
"T" = Tied
Note that the Championship and Invitational were discontinued from 2022. The Champions was discontinued from 2023.